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Differential Effects of Continuous and Intermittent 17β-Estradiol Replacement and Tamoxifen Therapy on the Prevention of Glomerulosclerosis : Modulation of the Mesangial Cell Phenotype in Vivo

Female ROP Os/+ mice are partially protected by endogenous estrogens against progressive glomerulosclerosis (GS) during their reproductive period; however, ovariectomy accelerates GS progression. We examined the effects of continuous and intermittent 17β-estradiol (E(2)) replacement and tamoxifen th...

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Detalhes bibliográficos
Main Authors: Karl, Michael, Berho, Mariana, Pignac-Kobinger, Judith, Striker, Gary E., Elliot, Sharon J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1698782/
https://ncbi.nlm.nih.gov/pubmed/16877338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2006.051255
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