Deficiency of αB crystallin augments ER stress induced apoptosis by enhancing mitochondrial dysfunction

Endoplasmic reticulum (ER) stress is linked to several pathological conditions including age-related macular degeneration. Excessive ER stress initiates cell death cascades which are mediated, in part, through mitochondrial dysfunction. Here, we identify αB crystallin as an important regulator of ER...

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Sonraí Bibleagrafaíochta
Main Authors: Dou, Guorui, Sreekumar, Parameswaran G, Spee, Christine, He, Shikun, Ryan, Stephen J, Kannan, Ram, Hinton, David R
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2012
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3454510/
https://ncbi.nlm.nih.gov/pubmed/22781655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2012.06.042
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