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Deficiency of αB crystallin augments ER stress induced apoptosis by enhancing mitochondrial dysfunction

Endoplasmic reticulum (ER) stress is linked to several pathological conditions including age-related macular degeneration. Excessive ER stress initiates cell death cascades which are mediated, in part, through mitochondrial dysfunction. Here, we identify αB crystallin as an important regulator of ER...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Dou, Guorui, Sreekumar, Parameswaran G, Spee, Christine, He, Shikun, Ryan, Stephen J, Kannan, Ram, Hinton, David R
פורמט: Artigo
שפה:Inglês
יצא לאור: 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3454510/
https://ncbi.nlm.nih.gov/pubmed/22781655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2012.06.042
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