Mechanism of RPE Cell Death in α-Crystallin Deficient Mice: A Novel and Critical Role for MRP1-Mediated GSH Efflux

Absence of α-crystallins (αA and αB) in retinal pigment epithelial (RPE) cells renders them susceptible to oxidant-induced cell death. We tested the hypothesis that the protective effect of α-crystallin is mediated by changes in cellular glutathione (GSH) and elucidated the mechanism of GSH efflux....

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Autors principals: Sreekumar, Parameswaran G., Spee, Christine, Ryan, Stephen J., Cole, Susan P. C., Kannan, Ram, Hinton, David R.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3307734/
https://ncbi.nlm.nih.gov/pubmed/22442691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033420
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