Creation and Preliminary Characterization of a Leptin Knockout Rat

Leptin, a cytokine-like hormone secreted mainly by adipocytes, regulates various pathways centered on food intake and energy expenditure, including insulin sensitivity, fertility, immune system, and bone metabolism. Here, using zinc finger nuclease technology, we created the first leptin knockout ra...

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Autors principals: Vaira, Sergio, Yang, Chang, McCoy, Aaron, Keys, Kelly, Xue, Shurong, Weinstein, Edward J., Novack, Deborah V., Cui, Xiaoxia
Format: Artigo
Idioma:Inglês
Publicat: Endocrine Society 2012
Matèries:
Technical Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3473197/
https://ncbi.nlm.nih.gov/pubmed/22948215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2012-1462
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