Creation and Preliminary Characterization of a Leptin Knockout Rat

Leptin, a cytokine-like hormone secreted mainly by adipocytes, regulates various pathways centered on food intake and energy expenditure, including insulin sensitivity, fertility, immune system, and bone metabolism. Here, using zinc finger nuclease technology, we created the first leptin knockout ra...

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Detalhes bibliográficos
Main Authors: Vaira, Sergio, Yang, Chang, McCoy, Aaron, Keys, Kelly, Xue, Shurong, Weinstein, Edward J., Novack, Deborah V., Cui, Xiaoxia
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2012
Assuntos:
Technical Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3473197/
https://ncbi.nlm.nih.gov/pubmed/22948215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2012-1462
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