Loading...
Microsome biocolloids for rapid drug metabolism and inhibition assessment by LC-MS
Rat liver microsomes attached to nanoparticles were used for LC-MS studies of CYP3A and 2E1 enzymes in metabolism of N-nitroso compounds. Using these biocolloids, turnover rates were measured within 2 min. Inhibitor IC(50) values for ketoconazole (KET) and 4-methylpyrazole (4-MEP) were estimated.
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2008
|
| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3473178/ https://ncbi.nlm.nih.gov/pubmed/19356087 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|