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Rapid LC-MS Drug Metabolite Profiling Using Microsomal Enzyme Bioreactors in a Parallel Processing Format

Silica nanoparticle bioreactors featuring thin films of enzymes and polyions were utilized in a novel high-throughput 96-well plate format for drug metabolism profiling. The utility of the approach was illustrated by investigating the metabolism of the drugs diclofenac (DCF), troglitazone (TGZ) and...

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Autors principals: Bajrami, Besnik, Zhao, Linlin, Schenkman, John B., Rusling, James F.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2795074/
https://ncbi.nlm.nih.gov/pubmed/19904994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac9015853
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