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Protein tyrosine phosphatase Shp2 (Ptpn11) plays an important role in maintenance of chromosome stability
Both activating and inactivating mutations in protein tyrosine phosphatase Ptpn11 (encoding Shp2) are associated with tumorigenesis. However, the underlying mechanisms remain unclear. Here we demonstrate that Shp2 plays an important role in mitosis, dysregulation of which results in chromosome insta...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3473170/ https://ncbi.nlm.nih.gov/pubmed/22890240 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-1495 |
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