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Protein tyrosine phosphatase Shp2 (Ptpn11) plays an important role in maintenance of chromosome stability

Both activating and inactivating mutations in protein tyrosine phosphatase Ptpn11 (encoding Shp2) are associated with tumorigenesis. However, the underlying mechanisms remain unclear. Here we demonstrate that Shp2 plays an important role in mitosis, dysregulation of which results in chromosome insta...

詳細記述

保存先:
書誌詳細
主要な著者: Liu, Xia, Zheng, Hong, Qu, Cheng-Kui
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3473170/
https://ncbi.nlm.nih.gov/pubmed/22890240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-12-1495
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