Chloroquine or Chloroquine-PI3K/Akt Pathway Inhibitor Combinations Strongly Promote γ-Irradiation-Induced Cell Death in Primary Stem-Like Glioma Cells

We asked whether inhibitors of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway, which is highly active in cancer stem cells (CSCs) and upregulated in response to genotoxic treatments, promote γ-irradiationγIR)-induced cell death in highly radioresistant, patient-derived stem-like glioma cells (...

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Main Authors: Firat, Elke, Weyerbrock, Astrid, Gaedicke, Simone, Grosu, Anca-Ligia, Niedermann, Gabriele
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3473017/
https://ncbi.nlm.nih.gov/pubmed/23091617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0047357
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