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FoxO proteins or loss of functional p53 maintain stemness of glioblastoma stem cells and survival after ionizing radiation plus PI3K/mTOR inhibition

Dual PI3K/mTOR inhibitors do not effectively radiosensitize glioblastoma multiforme stem cells (GBM-SCs), but p53-proficient GBM-SCs are more responsive than p53-deficient ones. Here, we found that p53-proficient, but not p53-deficient, GBM-SCs lost stemness and differentiated after γ-irradiation co...

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Bibliografske podrobnosti
izdano v:Oncotarget
Main Authors: Firat, Elke, Niedermann, Gabriele
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2016
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5342388/
https://ncbi.nlm.nih.gov/pubmed/27448972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10702
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