Patient-derived glioblastoma stem cells are killed by CD133-specific CAR T cells but induce the T cell aging marker CD57

The AC133 epitope of CD133 is a cancer stem cell (CSC) marker for many tumor entities, including the highly malignant glioblastoma multiforme (GBM). We have developed an AC133-specific chimeric antigen receptor (CAR) and show that AC133-CAR T cells kill AC133+ GBM stem cells (GBM-SCs) both in vitro...

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Détails bibliographiques
Publié dans:Oncotarget
Auteurs principaux: Zhu, Xuekai, Prasad, Shruthi, Gaedicke, Simone, Hettich, Michael, Firat, Elke, Niedermann, Gabriele
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2014
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4381586/
https://ncbi.nlm.nih.gov/pubmed/25426558
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