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Structural basis for the versatile interactions of Smad7 with regulator WW domains in TGF-β pathways
TGF-β and BMP signaling is mediated by Smads 1–5 (R-Smads and Co-Smads) and inhibited by Smad7, a major hub of regulation of TGF-β and BMP receptors by negative feedback and antagonistic signals. The transcription coactivator YAP and the E3 ubiquitin ligases Smurf1/2 and Nedd4L target R-Smads for ac...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3472128/ https://ncbi.nlm.nih.gov/pubmed/22921829 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2012.07.014 |
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