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Nitric oxide produced endogenously is responsible for hypoxia-induced HIF-1α stabilization in colon carcinoma cells
Hypoxia-inducible factor-1 alpha (HIF-1α) is a critical regulator of cellular responses to hypoxia. Under normoxic conditions, cellular HIF-1α level is regulated by hydroxylation by prolyl hydroxylases (PHDs), ubiquitylation and proteasomal degradation. During hypoxia, degradation decreases and its...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3472092/ https://ncbi.nlm.nih.gov/pubmed/22971010 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx300274a |
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