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Nitric oxide produced endogenously is responsible for hypoxia-induced HIF-1α stabilization in colon carcinoma cells

Hypoxia-inducible factor-1 alpha (HIF-1α) is a critical regulator of cellular responses to hypoxia. Under normoxic conditions, cellular HIF-1α level is regulated by hydroxylation by prolyl hydroxylases (PHDs), ubiquitylation and proteasomal degradation. During hypoxia, degradation decreases and its...

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Bibliografiska uppgifter
Huvudupphovsmän: Chowdhury, Rajdeep, Godoy, Luiz C., Thiantanawat, Apinya, Trudel, Laura J., Deen, William M., Wogan, Gerald N.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3472092/
https://ncbi.nlm.nih.gov/pubmed/22971010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx300274a
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