HIF1α Protein Stability Is Increased by Acetylation at Lysine 709

Lysine acetylation regulates protein stability and function. p300 is a component of the HIF-1 transcriptional complex and positively regulates the transactivation of HIF-1. Here, we show a novel molecular mechanism by which p300 facilitates HIF-1 activity. p300 increases HIF-1α (HIF1α) protein acety...

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Main Authors: Geng, Hao, Liu, Qiong, Xue, Changhui, David, Larry L., Beer, Tomasz M., Thomas, George V., Dai, Mu-Shui, Qian, David Z.
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2012
主題:
Cell Biology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471753/
https://ncbi.nlm.nih.gov/pubmed/22908229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.400697
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