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HIF1α Protein Stability Is Increased by Acetylation at Lysine 709
Lysine acetylation regulates protein stability and function. p300 is a component of the HIF-1 transcriptional complex and positively regulates the transactivation of HIF-1. Here, we show a novel molecular mechanism by which p300 facilitates HIF-1 activity. p300 increases HIF-1α (HIF1α) protein acety...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3471753/ https://ncbi.nlm.nih.gov/pubmed/22908229 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.400697 |
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