Basis of Miscoding of the DNA Adduct N(2),3-Ethenoguanine by Human Y-family DNA Polymerases

N(2),3-Ethenoguanine (N(2),3-ϵG) is one of the exocyclic DNA adducts produced by endogenous processes (e.g. lipid peroxidation) and exposure to bioactivated vinyl monomers such as vinyl chloride, which is a known human carcinogen. Existing studies exploring the miscoding potential of this lesion are...

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Detalhes bibliográficos
Main Authors: Zhao, Linlin, Pence, Matthew G., Christov, Plamen P., Wawrzak, Zdzislaw, Choi, Jeong-Yun, Rizzo, Carmelo J., Egli, Martin, Guengerich, F. Peter
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
DNA and Chromosomes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471744/
https://ncbi.nlm.nih.gov/pubmed/22910910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.403253
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