Activation of Peroxisome Proliferator-activated Receptor α (PPARα) Suppresses Hypoxia-inducible Factor-1α (HIF-1α) Signaling in Cancer Cells

Activation of peroxisome proliferator-activated receptor α (PPARα) has been demonstrated to inhibit tumor growth and angiogenesis, yet the mechanisms behind these actions remain to be characterized. In this study, we examined the effects of PPARα activation on the hypoxia-inducible factor-1α (HIF-1α...

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Detalhes bibliográficos
Main Authors: Zhou, Jundong, Zhang, Shuyu, Xue, Jing, Avery, Jori, Wu, Jinchang, Lind, Stuart E., Ding, Wei-Qun
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471732/
https://ncbi.nlm.nih.gov/pubmed/22932900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.367367
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