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Characterization of CSL (CBF-1, Su(H), Lag-1) Mutants Reveals Differences in Signaling Mediated by Notch1 and Notch2

Notch is a conserved signaling pathway that plays essential roles during embryonic development and postnatally in adult tissues; misregulated signaling results in human disease. Notch receptor-ligand interactions trigger cleavage of the Notch receptor and release of its intracellular domain (NICD) f...

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Detalhes bibliográficos
Main Authors: Yuan, Zhenyu, Friedmann, David R., VanderWielen, Bradley D., Collins, Kelly J., Kovall, Rhett A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471696/
https://ncbi.nlm.nih.gov/pubmed/22915591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.403287
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