dTIS11 Protein-dependent Polysomal Deadenylation Is the Key Step in AU-rich Element-mediated mRNA Decay in Drosophila Cells

The destabilization of AU-rich element (ARE)-containing mRNAs mediated by proteins of the TIS11 family is conserved among eukaryotes including Drosophila. Previous studies have demonstrated that Tristetraprolin, a human protein of the TIS11 family, induces the degradation of ARE-containing mRNAs thr...

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Bibliographic Details
Main Authors: Vindry, Caroline, Lauwers, Aurélien, Hutin, David, Soin, Romuald, Wauquier, Corinne, Kruys, Véronique, Gueydan, Cyril
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Gene Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471692/
https://ncbi.nlm.nih.gov/pubmed/22932903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.356188
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