ARE-mediated decay controls gene expression and cellular metabolism upon oxygen variations

Hypoxia triggers profound modifications of cellular transcriptional programs. Upon reoxygenation, cells return to a normoxic gene expression pattern and mRNA produced during the hypoxic phase are degraded. TIS11 proteins control deadenylation and decay of transcripts containing AU-rich elements (ARE...

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Udgivet i:Sci Rep
Main Authors: de Toeuf, Bérengère, Soin, Romuald, Nazih, Abdelkarim, Dragojevic, Marija, Jurėnas, Dukas, Delacourt, Nadège, Vo Ngoc, Long, Garcia-Pino, Abel, Kruys, Véronique, Gueydan, Cyril
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5980108/
https://ncbi.nlm.nih.gov/pubmed/29581565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-23551-8
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