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ARE-mediated decay controls gene expression and cellular metabolism upon oxygen variations
Hypoxia triggers profound modifications of cellular transcriptional programs. Upon reoxygenation, cells return to a normoxic gene expression pattern and mRNA produced during the hypoxic phase are degraded. TIS11 proteins control deadenylation and decay of transcripts containing AU-rich elements (ARE...
Enregistré dans:
| Publié dans: | Sci Rep |
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| Auteurs principaux: | , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group UK
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5980108/ https://ncbi.nlm.nih.gov/pubmed/29581565 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-23551-8 |
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