Rapid Proteasomal Degradation of Posttranscriptional Regulators of the TIS11/Tristetraprolin Family Is Induced by an Intrinsically Unstructured Region Independently of Ubiquitination

The TIS11/tristetraprolin (TTP) CCCH tandem zinc finger proteins are major effectors in the destabilization of mRNAs bearing AU-rich elements (ARE) in their 3′ untranslated regions. In this report, we demonstrate that the Drosophila melanogaster dTIS11 protein is short-lived due to its rapid ubiquit...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: Ngoc, Long Vo, Wauquier, Corinne, Soin, Romuald, Bousbata, Sabrina, Twyffels, Laure, Kruys, Véronique, Gueydan, Cyril
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4248748/
https://ncbi.nlm.nih.gov/pubmed/25246635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00643-14
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