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Regulation of double-stranded RNA-activated eukaryotic initiation factor 2α kinase by type 2 protein phosphatase in reticulocyte lysates

Protein synthesis initiation in reticulocyte lysates is inhibited by low concentrations (1-20 ng/ml) of double-stranded RNA (ds RNA) due to the activation of a ds RNA-dependent cAMP-independent protein kinase (ds I) that phosphorylates the α subunit of the eukaryotic initiation factor eIF-2. In lysa...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Petryshyn, Ray, Levin, Daniel H., London, Irving M.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1982
Fag:
Biological Sciences: Biochemistry
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC347157/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6292906/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.79.21.6512
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