Regulation of double-stranded RNA-activated eukaryotic initiation factor 2α kinase by type 2 protein phosphatase in reticulocyte lysates

Protein synthesis initiation in reticulocyte lysates is inhibited by low concentrations (1-20 ng/ml) of double-stranded RNA (ds RNA) due to the activation of a ds RNA-dependent cAMP-independent protein kinase (ds I) that phosphorylates the α subunit of the eukaryotic initiation factor eIF-2. In lysa...

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Autores principales: Petryshyn, Ray, Levin, Daniel H., London, Irving M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 1982
Materias:
Biological Sciences: Biochemistry
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC347157/
https://ncbi.nlm.nih.gov/pubmed/6292906
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