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Inhibition of protein synthesis initiation by oxidized glutathione: Activation of a protein kinase that phosphorylates the α subunit of eukaryotic initiation factor 2

Oxidized glutathione (GSSG) (0.02-0.5 mM) inhibits reticulocyte lysates by a mechanism similar to that observed in heme deficiency. Incubation of hemin-supplemented postribosomal supernates with GSSG results in the activation of a translational inhibitor [I(GSSG)]. The activation of I(GSSG) is enhan...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Ernst, Vivian, Levin, Daniel H., London, Irving M.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 1978
Предметы:
Online-ссылка:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC336061/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/279901/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.75.9.4110
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