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Inhibition of protein synthesis initiation by oxidized glutathione: Activation of a protein kinase that phosphorylates the α subunit of eukaryotic initiation factor 2

Oxidized glutathione (GSSG) (0.02-0.5 mM) inhibits reticulocyte lysates by a mechanism similar to that observed in heme deficiency. Incubation of hemin-supplemented postribosomal supernates with GSSG results in the activation of a translational inhibitor [I(GSSG)]. The activation of I(GSSG) is enhan...

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Bibliografiske detaljer
Main Authors: Ernst, Vivian, Levin, Daniel H., London, Irving M.
Format: Artigo
Sprog:Inglês
Udgivet: 1978
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC336061/
https://ncbi.nlm.nih.gov/pubmed/279901
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