Antibodies elicited against cis-diamminedichloroplatinum(II)-modified DNA are specific for cis-diamminedichloroplatinum(II)-DNA adducts formed in vivo and in vitro.

Rabbit antiserum elicited against calf thymus DNA modified to 4.4% (Pt drug/nucleotide ratio = 0.044) with the antitumor drug cis-diamminedichloroplatinum(II) (cis-DDP) contains antibodies specific for the Pt-modified DNA immunogen as well as for Pt-DNA adducts formed in both cultured mouse leukemia...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Poirier, M C, Lippard, S J, Zwelling, L A, Ushay, H M, Kerrigan, D, Thill, C C, Santella, R M, Grunberger, D, Yuspa, S H
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 1982
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC347142/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6959129/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.79.21.6443
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