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Synthesis and In Vivo Imaging of a (18)F-Labeled PARP1 Inhibitor Using a Bioorthogonal Scavenger-Assisted High Performance Method
Pedal to the metal: Using inverse Diels-Alder catalyst free TCO/Tz cycloadditions, we were able to quickly and selectively generate an (18)F-labeled AZD2281-derivative from multiple different scaffolds (A–E). Excess cold material was removed within minutes using a TCO scavenger resin. This protocol...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3471140/ https://ncbi.nlm.nih.gov/pubmed/21328671 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201006579 |
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