Imaging Therapeutic PARP Inhibition In Vivo through Bioorthogonally Developed Companion Imaging Agents

A number of small-molecule poly (ADP-ribose) polymerase (PARP) inhibitors are currently undergoing advanced clinical trials. Determining the distribution and target inhibitory activity of these drugs in individual subjects, however, has proven problematic. Here, we used a PARP agent for positron emi...

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Autors principals: Reiner, Thomas, Lacy, Jessica, Keliher, Edmund J, Yang, Katherine S, Ullal, Adeeti, Kohler, Rainer H, Vinegoni, Claudio, Weissleder, Ralph
Format: Artigo
Idioma:Inglês
Publicat: Neoplasia Press Inc. 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3323895/
https://ncbi.nlm.nih.gov/pubmed/22496617
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