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An essential role of metalloprotease-disintegrin ADAM12 in triple-negative breast cancer

In the absence of HER2 overexpression, triple-negative breast cancers (TNBCs) rely on signaling by epidermal growth factor receptor (EGFR/ErbB1/HER1) to convey growth signals and stimulate cell proliferation. Soluble EGF-like ligands are derived from their transmembrane precursors by ADAM proteases,...

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Bibliographic Details
Main Authors: Li, Hui, Duhachek-Muggy, Sara, Qi, Yue, Hong, Yan, Behbod, Fariba, Zolkiewska, Anna
Format: Artigo
Language:Inglês
Published: 2012
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3470813/
https://ncbi.nlm.nih.gov/pubmed/22926263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-012-2220-4
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