Metalloprotease-disintegrin ADAM12 actively promotes the stem cell-like phenotype in claudin-low breast cancer

BACKGROUND: ADAM12 is upregulated in human breast cancers and is a predictor of chemoresistance in estrogen receptor-negative tumors. ADAM12 is induced during epithelial-to-mesenchymal transition, a feature associated with claudin-low breast tumors, which are enriched in cancer stem cell (CSC) marke...

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Veröffentlicht in:Mol Cancer
Hauptverfasser: Duhachek-Muggy, Sara, Qi, Yue, Wise, Randi, Alyahya, Linda, Li, Hui, Hodge, Jacob, Zolkiewska, Anna
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2017
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5288940/
https://ncbi.nlm.nih.gov/pubmed/28148288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-017-0599-6
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