Fas Receptor Expression in Germinal-Center B Cells Is Essential for T and B Lymphocyte Homeostasis

Fas is highly expressed in activated and germinal center (GC) B cells but can potentially be inactivated by misguided somatic hypermutation. We employed conditional Fas-deficient mice to investigate the physiological functions of Fas in various B cell subsets. B cell-specific Fas-deficient mice deve...

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Detalhes bibliográficos
Main Authors: Hao, Zhenyue, Duncan, Gordon S., Seagal, Jane, Su, Yu-Wen, Hong, Claire, Haight, Jillian, Chen, Nien-Jung, Elia, Andrew, Wakeham, Andrew, Li, Wanda Y., Liepa, Jennifer, Wood, Geoffrey A., Casola, Stefano, Rajewsky, Klaus, Mak, Tak W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3470429/
https://ncbi.nlm.nih.gov/pubmed/18835195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2008.07.016
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