Active efflux of dasatinib from the brain limits efficacy against murine glioblastoma: broad implications for the clinical use of molecularly-targeted agents

Lignende værker

• Efflux Transporters at the Blood-Brain Barrier Limit Delivery and Efficacy of Cyclin-Dependent Kinase 4/6 Inhibitor Palbociclib (PD-0332991) in an Orthotopic Brain Tumor Model
  af: Parrish, Karen E., et al.
  Udgivet: (2015)
• Saturable Active Efflux by P-Glycoprotein and Breast Cancer Resistance Protein at the Blood-Brain Barrier Leads to Nonlinear Distribution of Elacridar to the Central Nervous System
  af: Sane, Ramola, et al.
  Udgivet: (2013)
• Distribution of Gefitinib to the Brain Is Limited by P-glycoprotein (ABCB1) and Breast Cancer Resistance Protein (ABCG2)-Mediated Active Efflux
  af: Agarwal, Sagar, et al.
  Udgivet: (2010)
• Pharmacokinetic Assessment of Efflux Transport in Sunitinib Distribution to the Brain
  af: Oberoi, Rajneet K., et al.
  Udgivet: (2013)
• Factors Influencing the CNS Distribution of a Novel MEK-1/2 Inhibitor: Implications for Combination Therapy for Melanoma Brain Metastases
  af: Vaidhyanathan, Shruthi, et al.
  Udgivet: (2014)