Active cathepsins B, L, and S in murine and human pancreatitis

Cathepsins regulate premature trypsinogen activation within acinar cells, a key initial step in pancreatitis. The identity, origin, and causative roles of activated cathepsins in pancreatic inflammation and pain are not defined. By using a near infrared-labeled activity-based probe (GB123) that cova...

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Bibliographic Details
Main Authors: Lyo, Victoria, Cattaruzza, Fiore, Kim, Tyson N., Walker, Austin W., Paulick, Margot, Cox, Daniel, Cloyd, Jordan, Buxbaum, James, Ostroff, James, Bogyo, Matthew, Grady, Eileen F., Bunnett, Nigel W., Kirkwood, Kimberly S.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2012
Subjects:
Inflammation/Immunity/Mediators
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3469694/
https://ncbi.nlm.nih.gov/pubmed/22899821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00073.2012
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