Transient receptor potential ion channels V4 and A1 contribute to pancreatitis pain in mice

The mechanisms of pancreatic pain, a cardinal symptom of pancreatitis, are unknown. Proinflammatory agents that activate transient receptor potential (TRP) channels in nociceptive neurons can cause neurogenic inflammation and pain. We report a major role for TRPV4, which detects osmotic pressure and...

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Detalhes bibliográficos
Main Authors: Ceppa, Eugene, Cattaruzza, Fiore, Lyo, Victoria, Amadesi, Silvia, Pelayo, Juan-Carlos, Poole, Daniel P., Vaksman, Natalya, Liedtke, Wolfgang, Cohen, David M., Grady, Eileen F., Bunnett, Nigel W., Kirkwood, Kimberly S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2010
Assuntos:
Neuroregulation and Motility
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2950679/
https://ncbi.nlm.nih.gov/pubmed/20539005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00433.2009
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