Hyperammonemia-mediated autophagy in skeletal muscle contributes to sarcopenia of cirrhosis

Hyperammonemia and sarcopenia (loss of skeletal muscle) are consistent abnormalities in cirrhosis and portosystemic shunting. We have shown that muscle ubiquitin-proteasome components are not increased with hyperammonemia despite sarcopenia. This suggests that an alternative mechanism of proteolysis...

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Main Authors: Qiu, Jia, Tsien, Cynthia, Thapalaya, Samjhana, Narayanan, Arvind, Weihl, Conrad Chris, Ching, James K., Eghtesad, Bijan, Singh, Kamini, Fu, Xiaoming, Dubyak, George, McDonald, Christine, Almasan, Alex, Hazen, Stanley L., Naga Prasad, Sathyamangla V., Dasarathy, Srinivasan
Format: Artigo
Sprog:Inglês
Udgivet: American Physiological Society 2012
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3469607/
https://ncbi.nlm.nih.gov/pubmed/22895779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00183.2012
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