Hyperammonemia-mediated autophagy in skeletal muscle contributes to sarcopenia of cirrhosis

Hyperammonemia and sarcopenia (loss of skeletal muscle) are consistent abnormalities in cirrhosis and portosystemic shunting. We have shown that muscle ubiquitin-proteasome components are not increased with hyperammonemia despite sarcopenia. This suggests that an alternative mechanism of proteolysis...

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Autors principals: Qiu, Jia, Tsien, Cynthia, Thapalaya, Samjhana, Narayanan, Arvind, Weihl, Conrad Chris, Ching, James K., Eghtesad, Bijan, Singh, Kamini, Fu, Xiaoming, Dubyak, George, McDonald, Christine, Almasan, Alex, Hazen, Stanley L., Naga Prasad, Sathyamangla V., Dasarathy, Srinivasan
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2012
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3469607/
https://ncbi.nlm.nih.gov/pubmed/22895779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00183.2012
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