Hyperammonemia in cirrhosis induces transcriptional regulation of myostatin by an NF-κB–mediated mechanism

Loss of muscle mass, or sarcopenia, is nearly universal in cirrhosis and adversely affects patient outcome. The underlying cross-talk between the liver and skeletal muscle mediating sarcopenia is not well understood. Hyperammonemia is a consistent abnormality in cirrhosis due to impaired hepatic det...

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Hlavní autoři: Qiu, Jia, Thapaliya, Samjhana, Runkana, Ashok, Yang, Yu, Tsien, Cynthia, Mohan, Maradumane L., Narayanan, Arvind, Eghtesad, Bijan, Mozdziak, Paul E., McDonald, Christine, Stark, George R., Welle, Stephen, Naga Prasad, Sathyamangla V., Dasarathy, Srinivasan
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2013
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3831479/
https://ncbi.nlm.nih.gov/pubmed/24145431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1317049110
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