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Hyperammonemia-mediated autophagy in skeletal muscle contributes to sarcopenia of cirrhosis

Hyperammonemia and sarcopenia (loss of skeletal muscle) are consistent abnormalities in cirrhosis and portosystemic shunting. We have shown that muscle ubiquitin-proteasome components are not increased with hyperammonemia despite sarcopenia. This suggests that an alternative mechanism of proteolysis...

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Detalhes bibliográficos
Main Authors: Qiu, Jia, Tsien, Cynthia, Thapalaya, Samjhana, Narayanan, Arvind, Weihl, Conrad Chris, Ching, James K., Eghtesad, Bijan, Singh, Kamini, Fu, Xiaoming, Dubyak, George, McDonald, Christine, Almasan, Alex, Hazen, Stanley L., Naga Prasad, Sathyamangla V., Dasarathy, Srinivasan
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3469607/
https://ncbi.nlm.nih.gov/pubmed/22895779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00183.2012
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