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Hyperammonemia-mediated autophagy in skeletal muscle contributes to sarcopenia of cirrhosis
Hyperammonemia and sarcopenia (loss of skeletal muscle) are consistent abnormalities in cirrhosis and portosystemic shunting. We have shown that muscle ubiquitin-proteasome components are not increased with hyperammonemia despite sarcopenia. This suggests that an alternative mechanism of proteolysis...
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| Main Authors: | , , , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3469607/ https://ncbi.nlm.nih.gov/pubmed/22895779 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00183.2012 |
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