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Identification of Cytoskeleton-Associated Proteins Essential for Lysosomal Stability and Survival of Human Cancer Cells

Microtubule-disturbing drugs inhibit lysosomal trafficking and induce lysosomal membrane permeabilization followed by cathepsin-dependent cell death. To identify specific trafficking-related proteins that control cell survival and lysosomal stability, we screened a molecular motor siRNA library in h...

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Bibliografiske detaljer
Main Authors: Groth-Pedersen, Line, Aits, Sonja, Corcelle-Termeau, Elisabeth, Petersen, Nikolaj H. T., Nylandsted, Jesper, Jäättelä, Marja
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3469574/
https://ncbi.nlm.nih.gov/pubmed/23071517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0045381
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