Depletion of Kinesin 5B Affects Lysosomal Distribution and Stability and Induces Peri-Nuclear Accumulation of Autophagosomes in Cancer Cells

BACKGROUND: Enhanced lysosomal trafficking is associated with metastatic cancer. In an attempt to discover cancer relevant lysosomal motor proteins, we compared the lysosomal proteomes from parental MCF-7 breast cancer cells with those from highly invasive MCF-7 cells that express an active form of...

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Detalhes bibliográficos
Main Authors: Cardoso, Carla M. P., Groth-Pedersen, Line, Høyer-Hansen, Maria, Kirkegaard, Thomas, Corcelle, Elizabeth, Andersen, Jens S., Jäättelä, Marja, Nylandsted, Jesper
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2647799/
https://ncbi.nlm.nih.gov/pubmed/19242560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004424
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