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Apoptosome-Independent Activation of the Lysosomal Cell Death Pathway by Caspase-9
The apoptosome, a heptameric complex of Apaf-1, cytochrome c, and caspase-9, has been considered indispensable for the activation of caspase-9 during apoptosis. By using a large panel of genetically modified murine embryonic fibroblasts, we show here that, in response to tumor necrosis factor (TNF),...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1636747/ https://ncbi.nlm.nih.gov/pubmed/16966373 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00716-06 |
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