Apoptosome-Independent Activation of the Lysosomal Cell Death Pathway by Caspase-9

The apoptosome, a heptameric complex of Apaf-1, cytochrome c, and caspase-9, has been considered indispensable for the activation of caspase-9 during apoptosis. By using a large panel of genetically modified murine embryonic fibroblasts, we show here that, in response to tumor necrosis factor (TNF),...

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Auteurs principaux: Gyrd-Hansen, Mads, Farkas, Thomas, Fehrenbacher, Nicole, Bastholm, Lone, Høyer-Hansen, Maria, Elling, Folmer, Wallach, David, Flavell, Richard, Kroemer, Guido, Nylandsted, Jesper, Jäättelä, Marja
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2006
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1636747/
https://ncbi.nlm.nih.gov/pubmed/16966373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00716-06
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