Heat Shock Protein 70 Promotes Cell Survival by Inhibiting Lysosomal Membrane Permeabilization

Heat shock protein 70 (Hsp70) is a potent survival protein whose depletion triggers massive caspase-independent tumor cell death. Here, we show that Hsp70 exerts its prosurvival function by inhibiting lysosomal membrane permeabilization. The cell death induced by Hsp70 depletion was preceded by the...

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Bibliographic Details
Main Authors: Nylandsted, Jesper, Gyrd-Hansen, Mads, Danielewicz, Agnieszka, Fehrenbacher, Nicole, Lademann, Ulrik, Høyer-Hansen, Maria, Weber, Ekkehard, Multhoff, Gabriele, Rohde, Mikkel, Jäättelä, Marja
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2004
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2211935/
https://ncbi.nlm.nih.gov/pubmed/15314073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20040531
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