Severe Thymic Atrophy in a Mouse Model of Skin Inflammation Accounts for Impaired TNFR1 Signaling

Transgenic mice expressing the caspase-cleaved form of the tyrosine kinase Lyn (LynΔN) develop a TNFα-dependent skin disease that accurately recapitulates human psoriasis. Participation of lymphocytes in this disease was confirmed by backcrossing LynΔN mice on a Rag-1 deficient background. The prese...

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Detalhes bibliográficos
Main Authors: Belhacéne, Nathalie, Gamas, Parvati, Gonçalvès, Diogo, Jacquin, Marie, Beneteau, Marie, Jacquel, Arnaud, Colosetti, Pascal, Ricci, Jean-Ehrland, Wakkach, Abdellilah, Auberger, Patrick, Marchetti, Sandrine
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3469485/
https://ncbi.nlm.nih.gov/pubmed/23071785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0047321
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