The caspase-cleaved form of LYN mediates a psoriasis-like inflammatory syndrome in mice

We showed previously that Lyn is a substrate for caspases, a family of cysteine proteases, involved in the regulation of apoptosis and inflammation. Here, we report that expression of the caspase-cleaved form of Lyn (LynΔN), in mice, mediates a chronic inflammatory syndrome resembling human psoriasi...

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Main Authors: Marchetti, Sandrine, Gamas, Parvati, Belhacène, Nathalie, Grosso, Sebastien, Pradelli, Ludivine A, Colosetti, Pascal, Johansen, Claus, Iversen, Lars, Deckert, Marcel, Luciano, Fréderic, Hofman, Paul, Ortonne, Nicolas, Khemis, Abdallah, Mari, Bernard, Ortonne, Jean-Paul, Ricci, Jean-Ehrland, Auberger, Patrick
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735179/
https://ncbi.nlm.nih.gov/pubmed/19590497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.183
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