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Intratumoral Immunotherapy of Established Solid Tumors with Chitosan/IL-12

IL-12 is a potent antitumor cytokine that exhibits significant clinical toxicities following systemic administration. We hypothesized that intratumoral (i.t.) administration of IL-12 coformulated with the biodegradable polysaccharide chitosan could enhance the antitumor activity of IL-12 while limit...

詳細記述

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書誌詳細
主要な著者: Zaharoff, David A, Hance, Kenneth W, Rogers, Connie J, Schlom, Jeffrey, Greiner, John
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3468951/
https://ncbi.nlm.nih.gov/pubmed/20664357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CJI.0b013e3181eb826d
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