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Intratumoral Immunotherapy of Established Solid Tumors with Chitosan/IL-12

IL-12 is a potent antitumor cytokine that exhibits significant clinical toxicities following systemic administration. We hypothesized that intratumoral (i.t.) administration of IL-12 coformulated with the biodegradable polysaccharide chitosan could enhance the antitumor activity of IL-12 while limit...

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Detalhes bibliográficos
Main Authors: Zaharoff, David A, Hance, Kenneth W, Rogers, Connie J, Schlom, Jeffrey, Greiner, John
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3468951/
https://ncbi.nlm.nih.gov/pubmed/20664357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CJI.0b013e3181eb826d
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