Genetic ablation of glutaredoxin-1 causes enhanced resolution of airways hyperresponsiveness and mucus metaplasia in mice with allergic airways disease

Protein-S-glutathionylation (PSSG) is an oxidative modification of reactive cysteines that has emerged as an important player in pathophysiological processes. Under physiological conditions, the thiol transferase, glutaredoxin-1 (Glrx1) catalyses deglutathionylation. Although we previously demonstra...

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Main Authors: Hoffman, Sidra M., Tully, Jane E., Lahue, Karolyn G., Anathy, Vikas, Nolin, James D., Guala, Amy S., van der Velden, Jos. L. J., Ho, Ye-Shih, Aliyeva, Minara, Daphtary, Nirav, Lundblad, Lennart K. A., Irvin, Charles G., Janssen-Heininger, Yvonne M. W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3468477/
https://ncbi.nlm.nih.gov/pubmed/22752969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00167.2012
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